Transcranial sensing of cerebral physiology to prevent perinatal hypoxic-ischemic encephalopathy & stroke

J. Kang, R. C. Kohler, S. Adams, E. M. Graham, and E. M. Boctor, “Light-emitting diode-based transcranial photoacoustic measurement of sagittal sinus oxyhemoglobin saturation in hypoxic neonatal piglets,” bioRxiv 262451, 24 Aug. 2020 J. Kang, E. M. Boctor, S. Adams, E. Kulikowicz, H. K. Zhang, R. C Koehler, E. M Graham “Validation of noninvasive photoacoustic measurements of…

Listening to membrane potential

J. Kang, S. D. Kadam, J. Elmore, B. J. Sullivan, H. Valentine, A. P. Malla, M. M. Harraz, A. Rahmim, J. U. Kang, L. M. Loew, M. Baumann, A. A. Grace, A. Gjedde, E. M. Boctor, and D. F. Wong, “Transcranial photoacoustic imaging of NMDA-evoked focal circuit dynamics in rat hippocampus,” Journal of Neural Engineering 17(2), 025001, 8…

Real-time nerve-sparing guidance during radical prostatectomy

J. Kang, H. N. D. Le, S. Karakus, J. U. Kang, A. L. Burnett, and E. M. Boctor, “Real-time, functional intra-operative localization of rat cavernous nerve network using near-infrared cyanine voltage-sensitive dye imaging,” Scientific Reports 10, 6618, 20 Apr. 2020. J. Kang, H. N. D. Le, S. Karakus, A. Burnett, J. U. Kang, E. M. Boctor, “Towards…

Ultrasound tomography reconstruction using deep learning methods

The current technique for prostate cancer detection is B-mode transrectal ultrasound (TRUS) guided systematic core needle biopsy. However, due to the limited sensitivity and capability of categorizing aggressiveness of prostate cancer in B-mode images, additional imaging modality such as magnetic resonance imaging (MRI) is necessary to support targeted biopsies. To reduce the imaging cost, we…

Economic photoacoustic imaging platforms

Our lab has been making effort toward popularizing photoacoustic imaging, and one of the aims is to lower the cost of photoacoustic imaging system. Instead of customizing stand-alone photoacoustic imaging systems, we propose to recycle or refurbish clinical ultrasound systems. The first challenge is the access to channel data. Unlike research platforms, clinical ultrasound system…

Lumbar puncture guidance with needle-based single-element ultrasound

Lumbar punctures (LPs) are interventional procedures that are used to collect cerebrospinal fluid. Since the target window is small, physicians have limited success conducting the procedure. The procedure is especially difficult for obese patients due to the increased distance between bone and skin surface. We propose a simple and direct needle insertion platform, enabling image formation by sweeping a needle with a single ultrasound element at the tip. The needle-shaped ultrasound transducer can not only sense the distance between the tip and a potential obstacle, such as bone, but also visually locate the structures by combining transducer location tracking and synthetic aperture focusing. The concept of the system was validated through a simulation that revealed robust image reconstruction under expected errors in tip localization. The initial prototype was built into a 14 G needle and was mounted on a holster equipped with a rotation shaft allowing one degree-of-freedom rotational sweeping and a rotation tracking encoder. We experimentally evaluated the system using a metal-wire phantom mimicking high reflection bone structures and human spinal bone phantom. Images of the phantoms were reconstructed, and the synthetic aperture reconstruction improved the image quality. These results demonstrate the potential of the system to be used as a real-time guidance tool for improving LPs.

Standard Plane Extraction from 3D Ultrasound with DQN agent

Automatically extract clinically valuable cross-section image of a free-hand 3D US volume within a deep reinforcement learning framework.